A very young apprentice, at the shop of Titian, arrives in Padua to meet the master Van Calcar. A task awaits him that leaves him stunned: complete the drawings made for Andrea Vesalio, a scientist who is writing a great treatise on anatomy. The boy is superstitious and would prefer to deal only with brushes and colors and not with corpses, but he cannot escape. Over time Vesalius even proves to be willing to explain his science to the boy. But the prejudice remains, as long as a murder involves the family of a girl who cares about the young apprentice and it will be Vesalius who will solve the mystery.